The metabolism of glycerophospholipids is different in eukaryotes and prokaryotes. Synthesis in prokaryotes involves the synthesis of glycerophospholipids phosphatidic acid and polar head groups. Phosphatidic acid synthesis in eukaryotes is different, there are two routes, one to the other toward phosphatidylcholine and phosphatidylethanolamine. It also describes the synthesis of other acylated glycerophospholipids as plasmalogens and sphingolipids. There are some diseases of sphingolipid synthesis of Tay-Sachs, Fabry, etc. Since eicosanoids, explained the synthesis of prostaglandins and leukotrienes.
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